Mizuki Sugimoto, Eita Sasaki, Hisashi Ohno, Takayuki Ikeno, Sota Yamada, Kenjiro Hanaoka “Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT)” Chemical and Pharmaceutical Bulletin, 72, 810-816, (2024). DOI: 10.1248/cpb.c24-00486
Kenichi Nagase, Marin Nagaoka, Junnosuke Matsuda, Naoto Kojima “Thermoresponsive block-copolymer brush-modified interfaces for effective fabrication of hepatocyte sheets” Materials & Design, 239, 112824, (2024). DOI: 10.1016/j.matdes.2024.112824
Kenichi Nagase, Junnosuke Matsuda, Ayako Takeuchi, Yuka Ikemoto “Hydration and dehydration behaviors of poly(N-isopropylacrylamide)-grafted silica beads” Surfaces and Interfaces, 40, 103058, (2023). DOI: 10.1016/j.surfin.2023.103058
Kenichi Nagase, Haruno Wakayama, Junnosuke Matsuda, Naoto Kojima, Hideko Kanazawa “Thermoresponsive mixed polymer brush to effectively control the adhesion and separation of stem cells by altering temperature” Materials Today Bio, 20, 100627, (2023). DOI: 10.1016/j.mtbio.2023.100627
Kouichi Yanagi, Toru Komatsu, Yuuta Fujikawa, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano “Development of Pathway-Oriented Screening to Identify Compounds to Control 2-Methylglyoxal Metabolism in Tumor Cells” Commun. Chem., 6, 68, (2023). DOI: 10.1038/s42004-023-00864-y
Hironobu Takahashi, Haruno Wakayama, Kenichi Nagase, Tatsuya Shimizu “Engineered Human Muscle Tissue from Multilayered Aligned Myofiber Sheets for Studies of Muscle Physiology and Predicting Drug Response” Small Methods, 7, 2200849, (2023). (Inside Front Cover)DOI: 10.1002/smtd.202200849
Kenichi Nagase, Kaichi Yamazaki, Yutaro Maekawa, Hideko Kanazawa “Thermoresponsive bio-affinity interfaces for temperature-modulated selective capture and release of targeted exosomes” Materials Today Bio, 18, 100521, (2023). DOI: 10.1016/j.mtbio.2022.100521
Yuta Amano, Takashi Misawa, Tamaki Miyazaki, Daisuke Ando, Tatsuo Koide, Ken-ichi Izutsu, Hideko Kanazawa, Kenjiro Hanaoka, Eiichi Yamamoto “Real-time in situ X-ray micro-computed tomography study of the effect of impurities on the crystallization of amorphous nifedipine” Journal of Pharmaceutical and Biomedical Analysis, 226, 115248, (2023). DOI: 10.1016/j.jpba.2023.115248
Eita Sasaki, Kenjiro Hanaoka “Chemical Approaches to Discover Selective Inhibitors of Sulfurtransferases and Transsulfuration Enzymes.” In Sulfurtransferases Essential Enzymes for Life, Noriyuki Nagahara, Ed.
Foundations and Frontiers in Enzymology, Elsevier, pp145-164 (2023).
Akihiro Nakada, Takuma Maruyama, Mako Kamiya, Kenjiro Hanaoka, Yasuteru Urano “Rapid visualization of deeply located tumors in vivo by intravenous administration of a γ-glutamyltranspeptidase-activated fluorescent probe” Bioconjugate Chemistry, 33, 523-529 (2022). DOI: 10.1021/acs.bioconjchem.2c00039
Kenichi Nagase, Kosuke Matsumoto, Hideko Kanazawa “Temperature-responsive mixed-mode column for the modulation of multiple interactions” Scientific Reports, 12(1), 4434 (2022). DOI: 10.1038/s41598-022-08475-8
Takeru Takagi, Tasuku Ueno, Keisuke Ikawa, Daisuke Asanuma, Yusuke Nomura, Shin-Nosuke Uno, Toru Komatsu, Mako Kamiya, Kenjiro Hanaoka, Chika Okimura, Yoshiaki Iwadate, Kenzo Hirose, Tetsuo Nagano, Kaoru Sugimura, Yasuteru Urano “Discovery of an F-actin-binding small molecule serving as a fluorescent probe and a scaffold for functional probes” Science advances, 7, eabg8585 (2021). DOI: 10.1126/sciadv.abg8585
Takayuki Ikeno, Kenjiro Hanaoka, Yasuteru Urano “Development of a small-molecule-based activatable photoacoustic probe” Methods in Enzymology, 657, 1-19 (2021). DOI: 10.1016/bs.mie.2021.06.041
Kouichi Yanagi, Toru Komatsu, Shusuke Ogihara, Takayoshi Okabe, Hirotatsu Kojima, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano “Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells” Cell Reports., 36(1), 109311 (2021). DOI: 10.1016/j.celrep.2021.109311
Eizo Marutani, Masanobu Morita, Shuichi Hirai, Shinichi Kai, Robert M. H. Grange, Yusuke Miyazaki, Fumiaki Nagashima, Lisa Traeger, Aurora Magliocca, Tomoaki Ida, Tetsuro Matsunaga, Daniel R. Flicker, Benjamin Corman, Naohiro Mori, Yumiko Yamazaki, Annabelle Batten, Rebecca Li, Tomohiro Tanaka, Takamitsu Ikeda, Akito Nakagawa, Dmitriy N. Atochin, Hideshi Ihara, Benjamin A. Olenchock, Xinggui Shen, Motohiro Nishida, Kenjiro Hanaoka, Christopher G. Kevil, Ming Xian, Donald B. Bloch, Takaaki Akaike, Allyson G. Hindle, Hozumi Motohashi, Fumito Ichinose “Sulfide catabolism ameliorates hypoxic brain injury” Nature communications, 12: 3108 (2021). DOI: 10.1038/s41467-021-23363-x
Nagase K, Edatsune G, Nagata Y, Matsuda J, Ichikawa D, S. Yamada, Hattori Y, Kanazawa H “Thermally-modulated cell separation columns using a thermoresponsive block copolymer brush as a packing material for the purification of mesenchymal stem cells” Biomaterials Science, 9, 7054-7064 (2021).DOI: 10.1039/D1BM00708D
Sebastien Jenni, Flavien Ponsot, Pierre Baroux, Lucile Collard, Takayuki Ikeno, Kenjiro Hanaoka, Valentin Quesneau, Kevin Renault and Anthony Romieu “Design, synthesis and evaluation of enzyme-responsive fluorogenic probes based on pyridine-flanked diketopyrrolopyrrole dyes” Spectrochim. Acta A Mol. Biomol. Spectrosc. Vol. 248, 119179 (2021). DOI: 10.1016/j.saa.2020.119179
Nagase K, Ishizawa Y, Inoue M, Kokubun M, Yamada S, Kanazawa H, Temperature-responsive spin column for sample preparation using an all-aqueous eluent, Analytica Chimica Acta, 1179, 338806, (2021).
Nagase K, Umemoto Y, Kanazawa H, Effect of pore diameter on the elution behavior of analytes from thermoresponsive polymer grafted beads packed columns, Scientific Reports, 11(1), 9976, (2021).
Homma K, Ohta Y, Minami K, Yoshikawa G, Nagase K, Akimoto A M, Yoshida R, Autonomous Nanoscale Chemomechanical Oscillation on the Self-Oscillating Polymer Brush Surface by Precise Control of Graft Density, Langmuir, 37(14), 4380-4386, (2021).
Nomoto D, Nagase K, Nakamura Y, Kanazawa H, Citterio D, Hiruta Y, Anion species-triggered antibody separation system utilizing a thermo-responsive polymer column under optimized constant temperature, Colloids and Surfaces B: Biointerfaces, 205, 111890, (2021).
Nagase K, Shimura M, Shimane R, Hanaya K, Yamada S, Akimoto A M, Sugai T, Kanazawa H, Selective capture and non-invasive release of cells using a thermoresponsive polymer brush with affinity peptides, Biomaterials Science, 9(3), 663-674, (2021) (Selected Front Cover Article).
Maekawa Y, Ayano E, Nagase K, Kanazawa H, Effective Separation for New Therapeutic Modalities Utilizing Temperature-Responsive Chromatography, Analytical Sciences, 37, 651-660, (2021)
総説
Honami Echizen, Eita Sasaki, Kenjiro Hanaoka “Recent advances in detection, isolation, and imaging techniques for sulfane sulfur-containing biomolecules” Biomolecules, 11, 1553 (2021). DOI: 10.3390/biom11111553
Nagase K, Thermoresponsive interfaces obtained using poly(N-isopropylacrylamide)-based copolymer for bioseparation and tissue engineering applications, Advances in Colloid and Interface Science, 295, 102487 (2021). DOI: 10.1016/j.cis.2021.102487
Honami Echizen and Kenjiro Hanaoka “Recent Advances in Probe Design to Detect Reactive Sulfur Species and in the Chemical Reactions Employed for Fluorescence Switching” J. Clin. Biochem. Nutr. Vol. 68, 9-17 (2021). DOI: 10.3164/jcbn.20-18
Rina Kunishige, Mai Mizoguchi, Asako Tsubouchi, Kenjiro Hanaoka, Yutaka Miura, Hiroshi Kurosu, Yasuteru Urano, Makoto Kuro-o, Masayuki Murata “Calciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells” Scientific Reports, 10, 20125 (2020). DOI: 10.1038/s41598-020-77308-3
Ryo Tachibana, Mako Kamiya, Akihiko Morozumi, Yoshiyuki Miyazaki, Hiroyoshi Fujioka, Aika Nanjo, Ryosuke Kojima, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Toshitad Yoshihara, Seiji Tobita, Yasuteru Urano “Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations” CHEMICAL COMMUNICATIONS, 56, 13173-13176 (2020). DOI: 10.1039/d0cc05126h
Naoya Nishi, Takashi Yamazawa, Tetsuo Sakka, Hiroki Hotta,Takayuki Ikeno, Kenjiro Hanaoka and Hiromi Takahashi “How Viscous is the Solid-like Structure at the Interface of Ionic Liquids? A Study Using Total Internal Reflection Fluorescence Spectroscopy with a Fluorescent Molecular Probe Sensitive to High Viscosity” Langmuir Vol. 36, 10397-10403 (2020). DOI: 10.1021/acs.langmuir.0c01528
Nagase K, Kitazawa S, Yamada S, Akimoto A M, Kanazawa H, Mixed polymer brush as a functional ligand of silica beads for temperature-modulated hydrophobic and electrostatic interactions, Analytica Chimica Acta, 1095, 1-13, (2020) (Selected Front Cover Article)
Nagase K, Uchikawa N, Hirotani T, Akimoto A M, Kanazawa H, Thermoresponsive anionic copolymer brush-grafted surfaces for cell separation, Colloids and Surfaces B: Biointerfaces, 185, 110565, (2020)
Nagase K, Shukuwa R, Takahashi H, Takeda N, Okano T, Enhanced mechanical properties and cell separation with thermal control of PIPAAm-brushed polymer-blend microfibers, Journal of Materials Chemistry B, 8, 6017-6026, (2020) (Selected Front Cover Article)
Nishimoto T, Matsukawa K, Nagase K, Kanazawa H, Akimoto A M, Yoshida R, Design of two complementary copolymers that work as a glue for cell-laden collagen gels, Chemical Communications, 56, 10545-10548, (2020)
Maekawa Y, Okamoto N, Okada Y, Nagase K, Kanazawa H, Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography, Scientific Reports, 10(1), 8828, (2020)
Nagase K, Ota A, Hirotani T, Yamada S, Akimoto A M, Kanazawa H, Thermoresponsive Cationic Block Copolymer Brushes for Temperature-Modulated Stem Cell Separation, Macromolecular Rapid Communications, 41(19), 2000308, (2020) (Selected Front Cover Article)
Maekawa Y, Yamazaki K, Ihara M, Nagase K, Kanazawa H, Simultaneous analysis of multiple oligonucleotides by temperature-responsive chromatography using a poly(N-isopropylacrylamide)-based stationary phase, Analytical and Bioanalytical Chemistry, 412, 5341-5351, (2020)
Nagase K, Ishii S, Ikeda K, Yamada S, Ichikawa D, Akimoto A, Hattori Y, Kanazawa H, Antibody drug separation using thermoresponsive anionic polymer brush modified beads with optimised electrostatic and hydrophobic interactions., Scientific Reports, 10, 11896, (2020)(新聞報道 有 3誌)
Nagase K, Kanazawa H, Temperature-responsive chromatography for bioseparations, Analytica Chimica Acta, 1138, 191-212, (2020) (Selected Front Cover Article)
Shao-An Wang, Chia-I Lin, Jiawei Zhang, Richiro Ushimaru, Eita Sasaki and Hung-wen Liu. “Studies of Lincosamide Formation Complete the Biosynthetic Pathway for Lincomycin A” Proc. Natl. Acad. Sci. U.S.A., 117, 24794–24801 (2020).
Eita Sasaki, Ryan M. Dragoman, Shiksha Mantri, Dmitry N. Dirin, Maksym V. Kovalenko and Donald Hilvert. “Self‐Assembly of Proteinaceous Shells Around Positively Charged Gold Nanomaterials Enhances Colloidal Stability in High Ionic Strength Buffers” ChemBioChem, 21, 74–79 (2020).
Tomohiro Takasugi, Kenjiro Hanaoka, Ayako Sasaki, Takayuki Ikeno, Toru Komatsu, Tasuku Ueno, Katsuya Yamada, Yasuteru Urano “Development of a Platform for Activatable Fluorescent Substrates of Glucose Transporters (GLUTs)” Bioorg. Med. Chem., Vol. 27, pp2122-2126 (2019). DOI: 10.1016/j.bmc.2019.02.055
Nagase K, Watanabe M, Zen F, Kanazawa H, Temperature-responsive mixed-mode column containing temperature-responsive polymer-modified beads and anionic polymer-modified beads, Analytica Chimica Acta, 1079, 220-229, (2019)
Nagase K, Inanaga D, Ichikawa D, Mizutani Akimoto A, Hattori Y, Kanazawa H, Temperature-modulated cell-separation column using temperature-responsive cationic copolymer hydrogel-modified silica beads, Colloids and Surfaces B: Biointerfaces, 178, 253-262, (2019) (Selected Front Cover Article)
Nagase K, Hasegawa M, Ayano E, Maitani Y, Kanazawa H, Effect of Polymer Phase Transition Behavior on Temperature-Responsive Polymer-Modified Liposomes for siRNA Transfection, International Journal of Molecular Sciences, 20(2), 430, (2019)
Maekawa-Matsuura M, Fujieda K, Maekawa Y, Nishimura T, Nagase K, Kanazawa H, LAT1-Targeting Thermoresponsive Liposomes for Effective Cellular Uptake by Cancer Cells, ACS Omega, 4(4), 6443-6451, (2019)
Nemoto R, Fujieda K, Hiruta Y, Hishida M, Ayano E, Maitani Y, Nagase K, Kanazawa H, Liposomes with temperature-responsive reversible surface properties, Colloids and Surfaces B: Biointerfaces, 176, 309-316, (2019)
Nakao M, Kim K, Nagase K, Grainger D W, Kanazawa H, Okano T, Phenotypic traits of mesenchymal stem cell sheets fabricated by temperature-responsive cell culture plate: structural characteristics of MSC sheets, Stem Cell Research & Therapy, 10(1), 353, (2019)
Nakao M, Inanaga D, Nagase K, Kanazawa H, Characteristic differences of cell sheets composed of mesenchymal stem cells with different tissue origins, Regenerative Therapy, 11, 34-40, (2019), IF: 2.286.
Li J, Kaku T, Tokura Y, Matsukawa K, Homma K, Nishimoto T, Hiruta Y, Akimoto A M, Nagase K, Kanazawa H, Shiratori S, Adsorption–Desorption Control of Fibronectin in Real Time at the Liquid/Polymer Interface on a Quartz Crystal Microbalance by Thermoresponsivity, Biomacromolecules, 20(4), 1748-1755, (2019)
Konishi T, Mizutani Akimoto A, Nishimoto T, Tokura Y, Tenjimbayashi M, Homma K, Matsukawa K, Kaku T, Hiruta Y, Nagase K, Kanazawa H, Shiratori S, Crosslinked Poly(N-Isopropylacrylamide)-Based Microfibers as Cell Manipulation Materials with Prompt Cell Detachment, Macromolecular Rapid Communications, 40(23), 1900464, (2019)
Homma K, Masuda T, Akimoto A M, Nagase K, Okano T, Yoshida R, Stable and Prolonged Autonomous Oscillation in a Self-Oscillating Polymer Brush Prepared on a Porous Glass Substrate, Langmuir, 35(30), 9794-9801, (2019)
Daria Ezeriņa, Yoko Takano, Kenjiro Hanaoka, Yasuteru Urano, Tobias P. Dick “N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production” Cell Chem. Biol., Vol. 25, pp447-459 (2018). DOI: 10.1016/j.chembiol.2018.01.011
Okubo K, Ikeda K, Oaku A, Hiruta Y, Nagase K, Kanazawa H, Protein purification using solid-phase extraction on temperature-responsive hydrogel-modified silica beads, Journal of Chromatography A, 1568, 38-48, (2018)
Nagase K, Yamato M, Okano T, Temperature‐responsive Polymers for Tissue Engineering, Temperature‐Responsive Polymers: Chemistry, Properties and Applications, 301-312 (2018).
Nagase K, Yamato M, Kanazawa H, Okano T, Poly(N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications, Biomaterials, 153, 27-48, (2018)
Nagase K, Okano T, Kanazawa H, Poly(N-isopropylacrylamide) based thermoresponsive polymer brushes for bioseparation, cellular tissue fabrication, and nano actuators, Nano-Structures & Nano-Objects, 16, 9-23, (2018)
Nagase K, Okano T, Thermoresponsive Polymer Brushes for Thermally Modulated Cell Adhesion and Detachment, Polymer and Biopolymer Brushes: For Materials Science and Biotechnology, pp. 361-375 (2018).
Matsuura M, Ohshima M, Hiruta Y, Nishimura T, Nagase K, Kanazawa H, LAT1-Targeting Thermoresponsive Fluorescent Polymer Probes for Cancer Cell Imaging, International Journal of Molecular Sciences, 19(6), 1646, (2018)
Masuda T, Akimoto A M, Furusawa M, Tamate R, Nagase K, Okano T, Yoshida R, Aspects of the Belousov–Zhabotinsky Reaction inside a Self-Oscillating Polymer Brush, Langmuir, 34(4), 1673-1680, (2018)
Akimoto A, Niitsu E, Nagase K, Okano T, Kanazawa H, Yoshida R, Mesenchylmal Stem Cell Culture on Poly(N-isopropylacrylamide) Hydrogel with Repeated Thermo-Stimulation, International Journal of Molecular Sciences, 19(4), 1253, (2018)
Kyle L. Fort, Michiel van de Waterbeemd, Dmitry Boll, Maria Reinhardt-Szyba, Mikhail E. Belov, Eita Sasaki, Reinhard Zschoche, Donald Hilvert, Alexander A. Makarov and Albert J. R. Heck, “Expanding the Structural Analysis Capabilities on an Orbitrap-Based Mass Spectrometer for Large Macromolecular Complexes” Analyst, 143, 100–105 (2018).
Yusuke Kimura, Toru Komatsu, Kouichi Yanagi, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yasuteru Urano “Development of Chemical Tools to Monitor and Control Isoaspartyl Peptide Methyltransferase Activity” Angew. Chem. Int. Ed., Vol.56, pp153-157 (2017). DOI: 10.1002/anie.201608677
Nagase K, Shukuwa R, Onuma T, Yamato M, Takeda N, Okano T, Micro/nano-imprinted substrates grafted with a thermoresponsive polymer for thermally modulated cell separation, Journal of Materials Chemistry B, 5(30), 5924-5930, (2017) (Selected Front Cover Article)
Nagase K, Sakurada Y, Onizuka S, Iwata T, Yamato M, Takeda N, Okano T, Thermoresponsive polymer-modified microfibers for cell separations, Acta Biomaterialia, 53, 81-92, (2017)
Nagase K, Nagumo Y, Kim M, Kim H-J, Kyung H-W, Chung H-J, Sekine H, Shimizu T, Kanazawa H, Okano T, Lee S-J, Yamato M, Local Release of VEGF Using Fiber Mats Enables Effective Transplantation of Layered Cardiomyocyte Sheets, Macromolecular Bioscience, 17(8), 1700073, (2017) (Selected Front Cover Article).
Masuda T, Kajisa T, Akimoto A M, Fujita A, Nagase K, Okano T, Sakata T, Yoshida R, Dynamic electrical behaviour of a thermoresponsive polymer in well-defined poly(N-isopropylacrylamide)-grafted semiconductor devices, RSC Advances, 7(55), 34517-34521, (2017)
Homma K, Masuda T, Akimoto A M, Nagase K, Itoga K, Okano T, Yoshida R, Fabrication of Micropatterned Self-Oscillating Polymer Brush for Direction Control of Chemical Waves, Small, 13(21), 1700041, (2017)
Eita Sasaki, Daniel Böhringer, Michiel van de Waterbeemd, Marc Leibundgut, Reinhard Zschoche, Albert J. R. Heck, Nenad Ban and Donald Hilvert. “Structure and Assembly of Scalable Porous Protein Cages” Nat. Commun., 8, 14663 (2017).
総説
Yoko Takano, Honami Echizen, Kenjiro Hanaoka
“Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling” Antioxid. Redox Signal., Vol.27, pp669-683 (2017).
Takayuki Ikeno, Tetsuo Nagano, Kenjiro Hanaoka
“Silicon-substituted Xanthene Dyes and their Unique Photophysical Properties for Fluorescent probes” Chem. Asian J., Vol.12, pp1435-1446 (2017).
Eita Sasaki and Donald Hilvert “Self-Assembling Proteinaceous Molecular Sponges” Cell Syst. 4, 368 (2017).
花岡 健二郎
“蛍光標識試薬”
Drug Delivery System 日本DDS学会，Vol.32, pp425-429 (2017).
2016年
原著論文
Toru Komatsu, Kentaro Yoshioka, Kenjiro Hanaoka, Takuya Terai Tasuku Ueno, Tetsuo Nagano, Yasuteru Urano “Identification of Lung Inflammation-Related Elevation of Acylamino Acid Releasing Enzyme (APEH) Activity Using an Enzymomics Approach” Chem. Pharm. Bull., Vol.11, pp1533-1538 (2016). DOI: 10.1248/cpb.c16-00540
Wei Chen, Armando Pacheco, Yoko Takano, Jacob J. Day, Kenjiro Hanaoka, Ming Xian “A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals” Angew. Chem. Int. Ed., Vol. 55, pp9993-9996 (2016). DOI: 10.1002/anie.201604892
Kentaro Yoshioka, Toru Komatsu, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Tetsuo Nagano, Yasuteru Urano “Discovery of pyruvylated peptide-metabolizing enzyme using a fluorescent substrate-based protein discovery technique” Chem. Commun., Vol.52, pp4377-4380 (2016). DOI: 10.1039/C6CC00829A
Tomoya Hirata, Takuya Terai, HisaoYamamura, Manabu Shimonishi, Toru Komatsu, Kenjiro Hanaoka, Tasuku Ueno, Yuji Imaizumi, Tetsuo Nagano, and Yasuteru Urano “A protein-coupled fluorescent probe to visualize potassium ion transition on cellular membranes” Anal. Chem., Vol.88, No.5, pp2693-2700 (2016). DOI: 10.1021/acs.analchem.5b03970
Nagase K, Okano T, Thermoresponsive-polymer-based materials for temperature-modulated bioanalysis and bioseparations, Journal of Materials Chemistry B, 4(39), 6381-6397, (2016)
Nagase K, Okano T, Bioseparation Using Thermoresponsive Polymers, Encyclopedia of Biocolloid and Biointerface Science, 220-230 (2016).
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Thermoresponsive anionic block copolymer brushes with a strongly anionic bottom segment for effective interactions with biomolecules, RSC Advances, 6(95), 93169-93179, (2016)
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Protein separations via thermally responsive ionic block copolymer brush layers, RSC Advances, 6(31), 26254-26263, (2016)
Nagase K, Hatakeyama Y, Shimizu T, Matsuura K, Yamato M, Takeda N, Okano T, Stem cell separation using thermoresponsive copolymer brushes having cationic charge, Proceedings 2015 International Symposium on MHS, 1-3, (2016).
Masuda T, Akimoto A M, Nagase K, Okano T, Yoshida R, Artificial cilia as autonomous nanoactuators: Design of a gradient self-oscillating polymer brush with controlled unidirectional motion, Science Advances, 2(8), e1600902, (2016)
Akimoto A M, Hasuike E, Tada H, Nagase K, Okano T, Kanazawa H, Yoshida R, Design of Tetra-arm PEG-crosslinked Thermoresponsive Hydrogel for 3D Cell Culture, Analytical Sciences, 32(11), 1203-1205, (2016)
Karsta Heinze, Eita Sasaki, Neil P. King, David Baker, Donald Hilvert, Gijs J. L. Wuite and Wouter H. Roos. “Protein Nanocontainers from Nonviral Origin: Testing the Mechanics of Artificial and Natural Protein Cages by AFM” J. Phys. Chem. B, 120, 5945–5952 (2016).
Eita Sasaki and Donald Hilvert. “Self-Assembly of Proteinaceous Multishell Structures Mediated by a Supercharged Protein” J. Phys. Chem. B, 120, 6089–6095 (2016).
Richiro Ushimaru, Chia-I Lin, Eita Sasaki and Hung-wen Liu. “Characterization of Enzymes Catalyzing Transformations of Cysteine S-Conjugated Intermediates in the Lincosamide Biosynthetic Pathway” ChemBioChem, 17, 1–7 (2016).
David R. Jackson, Xia Yu, Guojung Wang, Avinash B Patel, Jordi Calveras, Jesus F. Barajas, Eita Sasaki, Mikko Metsä-Ketelä, Hung-wen Liu, Jürgen Rohr and Shiou-Chuan Tsai. “Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE” ACS Chem. Biol., 11, 1137–1147 (2016).
総説
Yoko Takano, Kazuhito Shimamoto, Kenjiro Hanaoka
“Chemical tools for the study of hydrogen sulfide (H2S) and sulfane sulfur and their applications to biological studies” J. Clin. Biochem. Nutr., Vol.58, No.1, pp7-15 (2016).
Takuya Myochin, Kenjiro Hanaoka, Shimpei Iwaki, Tasuku Ueno, Toru Komatsu, Takuya Terai, Tetsuo Nagano, Yasuteru Urano “Development of a series of near-infrared dark quenchers based on Si-rhodamines and their application to fluorescent probes” J. Am. Chem. Soc., Vol.137, No.14, pp4759-4765 (2015). DOI: 10.1021/jacs.5b00246
Hideo Takakura, Ryosuke Kojima, Mako Kamiya, Eiji Kobayashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano, Yasuteru Urano “New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT” J. Am. Chem. Soc., Vol.137, No.12, pp4010-4013 (2015). DOI: 10.1021/ja511014w
Nagase K, Onuma T, Yamato M, Takeda N, Okano T, Enhanced Wettability Changes by Synergistic Effect of Micro/Nanoimprinted Substrates and Grafted Thermoresponsive Polymer Brushes, Macromolecular Rapid Communications, 36(22), 1965-1970, (2015) (Selected Front Cover Article).
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Thermoresponsive hydrophobic copolymer brushes modified porous monolithic silica for high-resolution bioseparation, RSC Advances, 5(81), 66155-66167, (2015)
Nagase K, Hatakeyama Y, Shimizu T, Matsuura K, Yamato M, Takeda N, Okano T, Thermoresponsive Cationic Copolymer Brushes for Mesenchymal Stem Cell Separation, Biomacromolecules, 16(2), 532-540, (2015)
Masuda T, Terasaki A, Akimoto A M, Nagase K, Okano T, Yoshida R, Control of swelling-deswelling behavior of a self-oscillating gel by designing the chemical structure, RSC Advances, 5(8), 5781-5787, (2015)
Masuda T, Akimoto A M, Nagase K, Okano T, Yoshida R, Design of Self-Oscillating Polymer Brushes and Control of the Dynamic Behaviors, Chemistry of Materials, 27(21), 7395-7402, (2015)
Grace Caldara-Festin, David R. Jackson, Jesus F. Barajas, Timothy R. Valentic, Avinash B. Patel, Stephanie Aguilar, MyChi Nguyen, Michael Vo, Avinash Khanna, Eita Sasaki, Hung-wen Liu and Shiou-Chuan Tsai. “Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases” Proc. Natl. Acad. Sci. U.S.A., 112, E6844–E6851 (2015).
総説
Kazuhito Shimamoto, Kenjiro Hanaoka
“Fluorescent probes for hydrogen sulfide (H2S) and sulfane sulfur and their applications to biological studies” Nitric Oxide, Vol.46, pp72-79 (2015).
Yu Kushida, Tetsuo Nagano, Kenjiro Hanaoka
“Silicon-substituted xanthene dyes and their applications in bioimaging” Analyst, Vol.140, pp685-695 (2015).
Halina Jurkowska, Heather B. Roman, Lawrence L. Hirschberger, Kiyoshi Sasakura, Tetsuo Nagano, Kenjiro Hanaoka, Jakub Krijt, Martha H. Stipanuk “Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate” Amino Acids, Vol.46, No.5, pp1353-1365 (2014). DOI: 10.1007/s00726-014-1700-8
Yoshimitsu Sagara, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Takashi Kato, Tetsuo Nagano “Covalent attachment of mechanoresponsive luminescent micelles to glasses and polymers in aqueous conditions” J. Am. Chem. Soc., Vol.136, No.11, pp4273-4280 (2014). DOI: 10.1021/ja412670g
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Thermoresponsive Anionic Copolymer Brushes Containing Strong Acid Moieties for Effective Separation of Basic Biomolecules and Proteins, Biomacromolecules, 15(10), 3846-3858, (2014)
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Monolithic Silica Rods Grafted with Thermoresponsive Anionic Polymer Brushes for High-Speed Separation of Basic Biomolecules and Peptides, Biomacromolecules, 15(4), 1204-1215, (2014)
Nagase K, Geven M, Kimura S, Kobayashi J, Kikuchi A, Akiyama Y, Grijpma D W, Kanazawa H, Okano T, Thermoresponsive Copolymer Brushes Possessing Quaternary Amine Groups for Strong Anion-Exchange Chromatographic Matrices, Biomacromolecules, 15(3), 1031-1043, (2014)
Matsuura K, Utoh R, Nagase K, Okano T, Cell sheet approach for tissue engineering and regenerative medicine, Journal of Controlled Release, 190(0), 228-239, (2014)
Ayano E, Suzuki Y, Nishio T, Nagata Y, Kanazawa H, Nagase K, Okano T, Liquid Chromatography-Mass Spectrometric Analysis of Dehydroepiandrosterone and Related Steroids Utilizing a Temperature-Responsive Stationary Phase, Chromatography, 131-138, (2014).
Eita Sasaki, Xuan Zhang, He G. Sun, Mei-Yeh Jade Lu, Tsung-lin Liu, Albert Ou, Jeng-yi Li, Yu-hsiang Chen, Steven E. Ealick and Hung-wen Liu. “Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis” Nature, 510, 427–431 (2014).
Chia-I Lin, Eita Sasaki, Aoshu Zhong and Hung-wen Liu. “In Vitro Characterization of LmbK and LmbO: Identification of GDP-D-erythro-a-D-gluco-octose as a Key Intermediate in Lincomycin A Biosynthesis” J. Am. Chem. Soc., 136, 906–909 (2014).
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Thermally Modulated Cationic Copolymer Brush on Monolithic Silica Rods for High-Speed Separation of Acidic Biomolecules, ACS Applied Materials & Interfaces, 5(4), 1442-1452, (2013)
Nagase K, Hatakeyama Y, Shimizu T, Matsuura K, Yamato M, Takeda N, Okano T, Hydrophobized Thermoresponsive Copolymer Brushes for Cell Separation by Multistep Temperature Change, Biomacromolecules, 14(10), 3423-3433, (2013)
Masuda T, Hidaka M, Murase Y, Akimoto A M, Nagase K, Okano T, Yoshida R, Self-Oscillating Polymer Brushes, Angewandte Chemie International Edition, 52(29), 7468-7471, (2013)
Yuichiro Koide, Mitsuyasu Kawaguchi, Yasuteru Urano, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai, Tetsuo Nagano "A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine" Chem. Commun., Vol.48, pp3091-3093 (2012). DOI: 10.1039/C2CC18011A
Tamura A, Nishi M, Kobayashi J, Nagase K, Yajima H, Yamato M, Okano T, Simultaneous Enhancement of Cell Proliferation and Thermally Induced Harvest Efficiency Based on Temperature-Responsive Cationic Copolymer-Grafted Microcarriers, Biomacromolecules, 13(6), 1765-1773, (2012)
Pirraco R P, Yamato M, Akiyama Y, Nagase K, Nakayama M, Marques A P, Reis R L, Okano T, Responsive Polymer Coatings for Smart Applications in Chromatography, Drug Delivery Systems, and Cell Sheet Engineering, Intelligent Surfaces in Biotechnology, pp. 321-354 (2012).
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, High Stability of Thermoresponsive Polymer-Brush-Grafted Silica Beads as Chromatography Matrices, ACS Applied Materials & Interfaces, 4(4), 1998-2008, (2012)
Nagase K, Mukae N, Kikuchi A, Okano T, Thermally Modulated Retention of Lymphocytes on Polymer-Brush-Grafted Glass Beads, Macromolecular Bioscience, 12(3), 333-340, (2012) (Selected Front Cover Article).
Nagase K, Kimura A, Shimizu T, Matsuura K, Yamato M, Takeda N, Okano T, Dynamically cell separating thermo-functional biointerfaces with densely packed polymer brushes, Journal of Materials Chemistry, 22(37), 19514-19522, (2012)
Kimura A, Nagase K, Shimizu T, Matsuura K, Yamato M, Takeda N, Okano T, Development of label-free cell separating system based on the functional surface with thermoresponsive polymer brush, Journal of Tissue Engineering and Regenerative Medicine, 6, 206, (2012).
Nagase K, Mukae N, Kikuchi A, Okano T, Lymphocyte separation columns using thermoresposnive polymer brush grafted glass beads, Journal of Tissue Engineering and Regenerative Medicine, 6, 207, (2012).
Nagase K, Kimura A, Shimizu T, Matsuura K, Yamato M, Takeda N, Okano T, Dynamically cell separating thermo-responsive biointerfaces having dense polymer brushes, 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, 6, 1105-1107, (2012).
Eita Sasaki, Chia-I. Lin, Ke-Yi Lin and Hung-wen Liu. “Construction of the Octose 8-Phosphate Intermediate in Lincomycin A Biosynthesis: Characterization of the Reactions Catalyzed by LmbR and LmbN” J. Am. Chem. Soc., 134, 17432–17435 (2012).
Masahiro Abo, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai, Toru Komatsu, Tetsuo Nagano "Development of a highly sensitive fluorescence probe for hydrogen peroxide" J. Am. Chem. Soc., Vol.133, No.27, pp10629-10637 (2011). DOI: 10.1021/ja203521e
Yuichiro Koide, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai, Tetsuo Nagano "Development of an Si-rhodamine-based far-red to near-infrared fluorescence probe selective for hypochlorous acid and applications for biological imaging" J. Am. Chem. Soc., Vol.133, No.15, pp5680-5682 (2011). DOI: 10.1021/ja111470n
Mitsuyasu Kawaguchi, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai, Tetsuo Nagano "Development of a highly selective fluorescence probe for alkaline phosphatase" Bioorg. Med. Chem. Lett., Vol.21, No.17, pp5088-5091 (2011). DOI: 10.1016/j.bmcl.2011.03.070
Yuichiro Koide, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai, Tetsuo Nagano "Evolution of group 14 rhodamines as platforms for near-infrared fluorescence probes utilizing photoinduced electron transfer" ACS Chem. Biol., Vol.6, No.6, pp600-608 (2011). DOI: 10.1021/cb1002416
Takahiro Egawa, Yuichiro Koide, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai, Tetsuo Nagano "Development of fluorescein analogue, TokyoMagenta, as a novel scaffold for fluorescence probes in red region" Chem. Commun., Vol.47, pp4162-4164 (2011). DOI: 10.1039/C1CC00078K
Takuya Myochin, Kazuki Kiyose, Kenjiro Hanaoka, Hirotatsu Kojima, Takuya Terai, Tetsuo Nagano "Rational design of ratiometric near-infrared fluorescent pH probes with various pKa values, based on aminocyanine" J. Am. Chem. Soc., Vol.133, No.10, pp3401-3409 (2011). DOI: 10.1021/ja1063058
Hideo Takakura, Ryosuke Kojima, Yasuteru Urano, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano "Aminoluciferins as functional bioluminogenic substrates of firefly luciferase" Chem. Asian J., Vol.6, No.7, pp1800-1810 (2011). DOI: 10.1002/asia.201000873
Naomi Takiguchi, Yuki Takahashi, Makiya Nishikawa, Yuriko Matsui, Yasushi Fukuhara, Daihi Oushiki, Kazuki Kiyose, Kenjiro Hanaoka, Tetsuo Nagano, Yoshinobu Takakura "Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice" Pharm. Res., Vol.28, No.4, pp702-711 (2011). DOI: 10.1007/s11095-010-0331-3
Nagase K, Yuk S F, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface, Journal of Materials Chemistry, 21(8), 2590-2593, (2011)
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Thermally-modulated on/off-adsorption materials for pharmaceutical protein purification, Biomaterials, 32(2), 619-627, (2011)
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Thermoresponsive Polymer Brush on Monolithic-Silica-Rod for the High-Speed Separation of Bioactive Compounds, Langmuir, 27(17), 10830-10839, (2011)
Nagase K, Watanabe M, Kikuchi A, Yamato M, Okano T, Thermo-Responsive Polymer Brushes as Intelligent Biointerfaces: Preparation via ATRP and Characterization, Macromolecular Bioscience, 11(3), 400-409, (2011) (Selected Front Cover Article).
Nagase K, Mizutani Akimoto A, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Effect of reaction solvent on the preparation of thermo-responsive stationary phase through a surface initiated atom transfer radical polymerization, Journal of Chromatography A, 1218(48), 8617-8628, (2011)
Kazuki Kiyose, Kenjiro Hanaoka, Daihi Oushiki, Tomomi Nakamura, Mayumi Kajimura, Makoto Suematsu, Hiroaki Nishimatsu, Takehiro Yamane, Takuya Terai, Tasunobu Hirata, Tatsuo Nagano "Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia" J. Am. Chem. Soc., Vol.132, No.45, pp15846-15848 (2010). DOI: 10.1021/ja105937q
Mitsuyasu Kawaguchi, Takayoshi Okabe, Takuya Terai, Kenjiro Hanaoka, Hirotatsu Kojima, Izumi Minegishi, Tetsuo Nagano "A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application for inhibitor screening" Chem. Eur. J., Vol.16, No.45, pp13479-13486 (2010). DOI: 10.1002/chem.201001077
Hiromi Sasaki, Kenjiro Hanaoka, Yasuteru Urano, Takuya Terai, Tetsuo Nagano "Design and synthesis of a novel fluorescence probe for Zn2+ based on the spirolactam ring−opening process of rhodamine derivatives" Bioorg. Med. Chem., Vol.19, No.3, pp1072-1078 (2011). DOI: 10.1016/j.bmc.2010.05.074
Hideo Takakura, Kiyoshi Sasakura, Tasuku Ueno, Yasuteru Urano, Takuya Terai, Kenjiro Hanaoka, Takashi Tsuboi, Tetsuo Nagano "Development of luciferin analogues bearing an amino group and their application as BRET donors" Chem. Asian J., Vol.5, No.9, pp2053-2061 (2010). DOI: 10.1002/asia.201000219
Daihi Oushiki, Hirotatsu Kojima, Takuya Terai, Makoto Arita, Kenjiro Hanaoka, Yasuteru Urano, Tetsuo Nagano "Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes" J. Am. Chem. Soc., Vol.132, No.8, pp2795-2801 (2010). DOI: 10.1021/ja910090v
Kenjiro Hanaoka, Yasuaki Muramatsu, Yasuteru Urano, Takuya Terai, Tetsuo Nagano "Design and synthesis of a highly sensitive off-on fluorescent chemosensor for zinc ion utilizing internal charge transfer" Chem. Eur. J., Vol.16, No.2, pp568-572 (2010). DOI: 10.1002/chem.200901591
Nagase K, Kumazaki M, Kanazawa H, Kobayashi J, Kikuchi A, Akiyama Y, Annaka M, Okano T, Thermoresponsive Polymer Brush Surfaces with Hydrophobic Groups for All-Aqueous Chromatography, ACS Applied Materials & Interfaces, 2(4), 1247-1253, (2010)
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Annaka M, Okano T, Preparation of Thermoresponsive Anionic Copolymer Brush Surfaces for Separating Basic Biomolecules, Biomacromolecules, 11(1), 215-223, (2010)
Mizutani A, Nagase K, Kikuchi A, Kanazawa H, Akiyama Y, Kobayashi J, Annaka M, Okano T, Effective separation of peptides using highly dense thermo-responsive polymer brush-grafted porous polystyrene beads, Journal of Chromatography B, 878(24), 2191-2198, (2010)
Mizutani A, Nagase K, Kikuchi A, Kanazawa H, Akiyama Y, Kobayashi J, Annaka M, Okano T, Preparation of thermo-responsive polymer brushes on hydrophilic polymeric beads by surface-initiated atom transfer radical polymerization for a highly resolutive separation of peptides, Journal of Chromatography A, 1217(38), 5978-5985, (2010)
Mizutani A, Nagase K, Kikuchi A, Kanazawa H, Akiyama Y, Kobayashi J, Annaka M, Okano T, Thermo-responsive polymer brush-grafted porous polystyrene beads for all-aqueous chromatography, Journal of Chromatography A, 1217(4), 522-529, (2010)
Idota N, Nagase K, Tanaka K, Okano T, Annaka M, Stereoregulation of Thermoresponsive Polymer Brushes by Surface-Initiated Living Radical Polymerization and the Effect of Tacticity on Surface Wettability, Langmuir, 26(23), 17781-17784, (2010)
Hattori Y, Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Hydration of poly(N-isopropylacrylamide) brushes on micro-silica beads measured by a fluorescent probe, Chemical Physics Letters, 491(4-6), 193-198, (2010)
Eita Sasaki and Hung-wen Liu. “Mechanistic Studies of the Biosynthesis of 2-Thiosugar: Evidence for the Formation of an Enzyme-Bound 2-Ketohexose Intermediate in BexX-Catalyzed Reaction” J. Am. Chem. Soc., 132, 15544–15546 (2010).
Eita Sasaki, Yasushi Ogasawara, and Hung-wen Liu. “A Biosynthetic Pathway for BE-7585A, a 2-Thiosugar-Containing Angucycline-Type Natural Product” J. Am. Chem. Soc., 132, 7405–7417 (2010).
総説
Kenjiro Hanaoka
"Development of responsive lanthanide-based magnetic resonance imaging and luminescent probes for biological applications" Chem. Pharm. Bull., Vol.58, No.10, pp1283-1294 (2010).
2009年
原著論文
Toru Komatsu, Yasuteru Urano, Yuuta Fujikawa, Tomonori Kobayashi, Hirotatsu Kojima, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano "Development of 2,6-carboxy-substituted boron dipyrromethene (BODIPY) as a novel scaffold of ratiometric fluorescent probes for live cell imaging" Chem. Commun., pp7015-7017 (2009). DOI: 10.1039/B917209B
Saki Izumi, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai, Tetsuo Nagano “A simple and effective strategy to increase the sensitivity of fluorescence probes in living cells” J. Am. Chem. Soc., Vol.131, No.29, pp10189-10200 (2009). DOI: 10.1021/ja902511p
Kazuki Kiyose, Sakiko Aizawa, Eita Sasaki, Hirotatsu Kojima, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai, Tetsuo Nagano “Molecular design strategies for near-infrared ratiometric fluorescent probes based on unique spectral properties of aminocyanines” Chem. Eur. J., Vol.15, No.36, pp9191-9200 (2009). DOI: 10.1002/chem.200900035
Yuichiro Koide, Yasuteru Urano, Akira Yatsushige, Kenjiro Hanaoka, Takuya Terai, Tetsuo Nagano “Design and development of enzymatically activatable photosensitizer based on unique characteristics of thiazole orange” J. Am. Chem. Soc., Vol.131, No.17, pp6058-6059 (2009). DOI: 10.1021/ja900443b
Nagase K, Kobayashi J, Okano T, Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering, Journal of The Royal Society Interface, 6(Suppl 3), S293-S309, (2009)
Kazuki Kiyose, Sakiko Aizawa, Eita Sasaki, Hirotatsu Kojima, Kenjiro Hanaoka, Takuya Terai, Yasuteru Urano and Tetsuo Nagano. “Molecular Design Strategies for Near-Infrared Ratiometric Fluorescent Probes Based on the Unique Spectral Properties of Aminocyanines”, Chem.-Eur. J., 15, 9191–9200 (2009).
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Effects of Graft Densities and Chain Lengths on Separation of Bioactive Compounds by Nanolayered Thermoresponsive Polymer Brush Surfaces, Langmuir, 24(2), 511-517, (2008)
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Preparation of Thermoresponsive Cationic Copolymer Brush Surfaces and Application of the Surface to Separation of Biomolecules, Biomacromolecules, 9(4), 1340-1347, (2008)
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Annaka M, Kanazawa H, Okano T, Influence of Graft Interface Polarity on Hydration/Dehydration of Grafted Thermoresponsive Polymer Brushes and Steroid Separation Using All-Aqueous Chromatography, Langmuir, 24(19), 10981-10987, (2008)
Kenjiro Hanaoka, Angelo Josue M. Lubag, Aminta Castillo-Muzquiz, Thomas Kodadek, A. Dean Sherry “The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain” Magn. Reson. Imaging, Vol.26, No.5, pp608-617 (2008). DOI: 10.1016/j.mri.2007.11.002
Kenjiro Hanaoka, Kazuya Kikuchi, Shigeru Kobayashi, Tetsuo Nagano “Time-resolved long-lived luminescence imaging method employing luminescent lanthanide probes with a new microscopy system” J. Am. Chem. Soc., Vol.129, No.44, pp13502-13509 (2007). DOI: 10.1021/ja073392j
Michiaki Kumagai, Yutaka Imai, Teisaku Nakamura, Yuichi Yamasaki, Masaki Sekino, Shoogo Ueno, Kenjiro Hanaoka, Kazuya Kikuchi, Tetsuo Nagano, Eiji Kaneko, Kentaro Shimokado, Kazunori Kataoka “Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging” Colloids Surf. B: Biointerfaces, Vol.56, No.1-2, pp174-181 (2007). DOI: 10.1016/j.colsurfb.2006.12.019
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T, Interfacial Property Modulation of Thermoresponsive Polymer Brush Surfaces and Their Interaction with Biomolecules, Langmuir, 23(18), 9409-9415, (2007).
Annaka M, Yahiro C, Nagase K, Kikuchi A, Okano T, Real-time observation of coil-to-globule transition in thermosensitive poly(N-isopropylacrylamide) brushes by quartz crystal microbalance, Polymer, 48(19), 5713-5720, (2007)
Toru Komatsu, Kazuya Kikuchi, Hideo Takakusa, Kenjiro Hanaoka, Tasuku Ueno, Mako Kamiya, Yasuteru Urano, Tetsuo Nagano “Design and synthesis of an enzyme activity-based labeling molecule with fluorescence spectral change” J. Am. Chem. Soc., Vol.128, No.50, pp15946-15947 (2006). DOI: 10.1021/ja0657307
Kenjiro Hanaoka, Kazuya Kikuchi, Hirotatsu Kojima, Yasuteru Urano, Tetsuo Nagano “Development of a zinc ion-selective luminescent lanthanide chemosensor for biological applications” J. Am. Chem. Soc., Vol.126, No.39, pp12470-12476 (2004). DOI: 10.1021/ja0469333
Nagase K, Kohori F, Sakai K, Nishide H, Rearrangement of hollow fibers for enhancing oxygen transfer in an artificial gill using oxygen carrier solution, Journal of Membrane Science, 254(1-2), 207-217, (2005),
Nagase K, Kohori F, Sakai K, Oxygen transfer performance of a membrane oxygenator composed of crossed and parallel hollow fibers, Biochemical Engineering Journal, 24(2), 105-113, (2005)
Nagase K, Hasegawa U, Kohori F, Sakai K, Nishide H, The photoresponse of a molybdenum porphyrin makes an artificial gill feasible, Journal of Membrane Science, 249(1-2), 235-243, (2005)
Eita Sasaki, Hirotatsu Kojima, Hiroaki Nishimatsu, Yasuteru Urano, Kazuya Kikuchi, Yasunobu Hirata and Tetsuo Nagano. “Highly Sensitive Near-Infrared Fluorescence Probes for Nitric Oxide and Their Application to Isolated Organs” J. Am. Chem. Soc., 127, 3684–3685 (2005).
Nagase K, Hasegawa U, Kohori F, Sakai K, Nishide H, A Photoresponsive Artificial Gill, Proceedings of Asian Pacific Confederation of Chemical Engineering Congress, 489-494, (2004)
Nagase K, Kohori F, Sakai K, Efficiency of biological and artificial gills,, Bio-mechanisms of Swimming and Flying, 188-199, (2004)
Nagase K, Kohori F, Sakai K, A Compact Artificial Gill using a Hemoglobin Solution as a Thermo-Responsive Oxygen Carrier, Proceedings of Asian Pacific Confederation of Chemical Engineering Congress, 407-494, (2004)
Nagase K, Kohori F, Sakai K, Designing an Artificial Gill Using Oxygen Carrier Solution for Effective Supply of Oxygen to Underwater Closed Spaces, Journal of Research in Science and Engineering, 1, 31-36, (2003).
Nagase K, Kohori F, Sakai K, Development of a compact artificial gill using concentrated hemoglobin solution as the oxygen carrier, Journal of Membrane Science, 215(1-2), 281-292, (2003)
Kenjiro Hanaoka, Kazuya Kikuchi, Yasuteru Urano, Michiko Narazaki, Takashi Yokawa, Shigeru Sakamoto, Kentaro Yamaguchi, Tetsuo Nagano “Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion” Chem. Biol., Vol.9, No.9, pp1027-1032 (2002). DOI: 10.1016/s1074-5521(02)00216-8
Nagase K, Matsuda N, Sakai K, Optimum control of oxygen affinity of hemoglobin as an oxygen carrier solution for an artificial gill, Journal of Artificial Organs, 5(1), 44-49, (2002).
Kenjiro Hanaoka, Kazuya Kikuchi, Yasuteru Urano, Tetsuo Nagano “Selective sensing of zinc ions with a novel magnetic resonance imaging contrast agent” J. Chem. Soc. –Perkin Trans. 2, pp1840-1843 (2001). DOI: 10.1039/B100994J
